I am encountering a problem with Android ADB debugging through USB.

Using Macbook Air 2013 and trying to connect Nexus 6 dev phone.

On the MAC Android Studio, android latest sdk is installed.

When I do 

    adb kill-server
    adb devices

I get:

    adb I   661  9881 usb_osx.cpp:259] Found vid=18d1 pid=**** serial=*****
    adb I   661  9881 usb_osx.cpp:259] 
    adb E   661  9881 usb_osx.cpp:331] Could not open interface: e00002c5
    adb E   661  9881 usb_osx.cpp:265] Could not find device interface

So it found the device, vendor id, product id and serial match what I find in the system information for the Nexus 6.

Following suggestions found online I tried - but no success - the following to resolve:

- dis- and reenabling debugging mode on the phone, also switching between USB configs for charging, MTP, PTP, RNDIS, Audio Source, MIDI, always making sure the authoriztation for the Mac&#39;s RSA fingerprint is given

- closing Android Studio / DDMS, killing adb through &#39;kill-server&#39; command as well as killing process through Apple activity monitor

- run adb as root

- reboot the Mac several times

- reboot the Nexus 6

- reinstall Android SDK completely

- tried with another debugging enabled Android Device (Samsung Galaxy Tab, also here adb found correct device info but cannot access interface with same error)

- tried with 3 different USB cables, all cables which were originally shipped with Android devices

Through google I learned that error code e00002c5 means the device is already in use by another driver. 

I had recently installed Sophos Home Antivir. Thinking that this might prevent ADB from opening the device interface, I uninstalled Sophos completely with the provided uninstaller and rebooted the Mac.

Any hint is appreciated: 

- which steps to resolve?

- as e00002c5 seems to be a clear indicator that another driver has the device in use, how to find out which process that is and how to stop it from doing that


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macbook adb cannot open interface